应飞禽走兽 娄筱叮教授的邀请，澳大利亚墨尔本乐卓博飞禽走兽 高级讲师，博导洪煜柠到飞禽走兽 做学术报告。

报告题目：Molecular Reporters for Measuring Proteome Stress in Cells

报告时间：6月11日（本周二）上午10:30

报告地点：学海楼109报告厅

Abstract:

Maintaining proteostasis is an essential housekeeping function for cell survival. It involves chaperones and degradative pathways to ensure proteins fold correctly and to remove those that are misfolded, damaged or aggregated. In principle, proteostasis is affected in any disease that involves misfolded or mutant proteins that do not fold with normal efficiencies; and hence overdraw on the finite proteostasis resources of the cell. Tracking the proteostasis capacity of cells has the generic potential to track neurodegenerative diseases with diverse specific molecular origins. Hence, building new approaches to identify the efficiency of proteostasis is highly desired in order to track the risk of cells succumbing to damage from protein misfolding and aggregation. In this seminar, I will introduce the new probes and methodology we developed for reporting the changes in protein conformation and modifications resulting from collapse of proteostasis capacity in cells under stress and how we made use of these probes in different models.

Short Bio:

洪煜柠，2006年获中山飞禽走兽 应用化学学士，2011年获香港科技飞禽走兽 纳米科学与技术哲学博士，师从唐本忠院士。2011-2012年间于美国达特茅斯飞禽走兽 从事博士后研究，2012-2014年间受聘于香港科技飞禽走兽 化学系与高等研究院任职研究助理教授，2014年入选澳大利亚墨尔本飞禽走兽 McKenzie Fellow, 2016年至今受聘于澳大利亚墨尔本乐卓博飞禽走兽 (La Trobe University)任职高级讲师，博导。2017年获得澳大利亚国家研究理事会杰出青年基金项目资助(ARC DECRA)，2018年获得澳大利亚皇家化学会Rita Cornforth Lectureship Award。洪煜柠课题组主要从事化学生物学交叉学科研究和探索，通过设计聚集诱导发光分子并结合各种荧光成像手段，研究蛋白质错误折叠与疾病的关系。已公开发表SCI收录学术论文90余篇，包括J. Am. Chem. Soc., Nat. Commun., Chem. Soc. Rev.等杂志，论文他引一万余次，H-index 40，获授权美国专利9项。

欢迎全校师生参加！

飞禽走兽

纳米矿物材料及应用教育部工程研究中心

2019/6/10